STRAND

Pronunție (USA): (GB):

Traducere în limba română

strand¹ I. substantiv

1. mal, ţărm, margine (a mării), uscat.

2. (geogr.) întinsură.

strand¹ II. verb A. tranzitiv

a arunca sau a împinge pe uscat / la mal; a face să eşueze (şi fig.).

strand¹ II. verb B. intranzitiv

(mar.) a eşua, a fi aruncat pe uscat / la mal.

strand² I. substantiv

1. jurubiţă.

2. şuviţă;

strands of hair şuviţe de păr.

3. (tehn.) vână, toron (de cablu etc.);

wire strand toron metalic;

central strand inimă (de cablu).

4. (electr.) liţă, toron.

5. (text.) fir (al unei ţesături); fibră.

6. (fig.) trăsătură (de caracter).

strand² II. verb tranzitiv

a torsada a răsuci, a împleti.

Exemple de propoziții și/sau fraze:

The building blocks of the strands are known as nucleotides.

(Structural Snapshots of Damaged DNA, NIH)

The resulting bioactive mono-alkyltriazene species are capable of alkylating nucleophilic residues in the immediate vicinity such as N-7 and/or O-6 sites of guanine, thereby causes intra- or inter-stranded DNA cross-links and trigger apoptosis.

(Mitozolomide, NCI Thesaurus)

Anthracycline analogue GPX-150 intercalates DNA and impedes the activity of topoisomerase II, inducing single and double-stranded breaks in DNA; inhibiting DNA replication and/or repair, transcription, and protein synthesis; and activating tumor cell apoptosis.

(Anthracycline Analogue GPX-150, NCI Thesaurus)

Although the exact relationship between DNA binding and its activity has yet to be fully elucidated, amsacrine intercalates DNA through its acridine moiety, and its nonintercalative headgroup impedes topoisomerase II activity, augmenting enzyme-mediated DNA cleavage and resulting in DNA double-strand breaks.

(Amsacrine Lactate, NCI Thesaurus)

IFN alpha is a type I interferon produced by peripheral blood leukocytes or lymphoblastoid cells when exposed to live or inactivated virus, double-stranded RNA, or bacterial products and is the primary interferon produced by virus-induced leukocyte cultures.

(Natural IFN-alpha OPC-18, NCI Thesaurus)

The last flood had lifted her, and had there been much wind or a strong tide current, as in the southern anchorage, we should never have found her more, or found her stranded beyond help.

(Treasure Island, de Robert Louis Stevenson)

The milatuzumab moiety of this ADC selectively binds to CD74 on tumor cell surfaces; upon internalization, the doxorubicin moiety is released, where it intercalates between base pairs in the DNA helix and inhibits topoisomerase II, thereby preventing DNA replication and increasing double-strand breakage.

(Milatuzumab-Doxorubicin Antibody-Drug Conjugate, NCI Thesaurus)

I bought a second-hand dumb-waiter for this dinner-party, in preference to re-engaging the handy young man; against whom I had conceived a prejudice, in consequence of meeting him in the Strand, one Sunday morning, in a waistcoat remarkably like one of mine, which had been missing since the former occasion.

(David Copperfield, de Charles Dickens)

Upon internalization, the prodrug moiety is released and activated and binds to double-stranded B-DNA within the minor groove, thereby alkylating the -3 position of adenine, which may result in the inhibition of cellular proliferation of tumor cells that overexpress CD70.

(Anti-CD70 Antibody-Drug Conjugate MDX-1203, NCI Thesaurus)

When nucleotides are damaged, DNA strands become unstable, which may lead to diseases such as cancer, diabetes and Alzheimer's Disease.

(Structural Snapshots of Damaged DNA, NIH)

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