PROTEOLYTIC

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proteolytic adjectiv

(fiziol.) proteolitic.

Exemple de propoziții și/sau fraze:

Beta-amyloid fragments are derived from proteolytic processing of amyloid precursor protein (APP) in neurons, and the subsequent release of fragments into the extracellular space.

(Amyloid Beta-Peptide Pathway, NCI Thesaurus/BIOCARTA)

Activation of Notch receptors by DLL4 stimulates proteolytic cleavage of the Notch intracellular domain (NICD); after cleavage, NICD is translocated to the nucleus and mediates the transcriptional regulation of a variety of genes involved in vascular development.

(Anti-DLL4 Monoclonal Antibody MEDI0639, NCI Thesaurus)

The proteolytic processing of Notch resembles in several ways the proteolytic processing of amyloid precursor protein (APP) that is implicated in plaque formation in Alzheimer's disease, with TACE and Presenilin-1 implicated in proteolytic processing of both Notch and APP.

(Notch Proteolysis and Signaling Pathway, NCI Thesaurus/BIOCARTA)

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