MODULATE

Pronunție (USA): (GB):

Traducere în limba română

modulate verb A. tranzitiv

a modula, a înmuia, a îndulci (vocea); a adapta, a ajusta.

modulate verb B. intranzitiv

(muz.) a trece dintr-o tonalitate în alta.

Exemple de propoziții și/sau fraze:

Natural human interferon alpha OPC-18 binds to cell-surface IFN alpha receptors (IFNARs), resulting in the transcription and translation of genes whose products mediate antiviral, antiproliferative, and immune-modulating effects.

(Natural IFN-alpha OPC-18, NCI Thesaurus)

Other pathways modulate the role of NF-kB in H. influenzae pathogenesis.

(NFKB Activation Pathway, NCI Thesaurus/BIOCARTA)

Calcium release induced by PARs activates PKC, modulating integrin alpha IIB beta 3 (glycoprotein IIb/IIIa) and opening integrin ligand binding sites to contribute to platelet aggregation.

(Aspirin Inhibition of Platelet Activation Pathway, NCI Thesaurus/BIOCARTA)

As it represents a poor substrate for P-glycoprotein (P-gp), multi-drug resistance protein (MRP-1) and breast cancer resistance protein (BCRP) mediated efflux, ortataxel modulates multi-drug resistance mechanisms and may be useful for treating multi-drug resistant tumors that express Pgp, MRP-1 and BCRP.

(Ortataxel, NCI Thesaurus)

Exposure to PC-SPES in vitro has resulted in a decreased expression of genes encoding cell cycle regulatory proteins as well as an upregulation of genes that modulate apoptosis in both androgen-dependent and androgen-independent cells.

(PC-SPES, NCI Thesaurus)

Previous studies have suggested that both coffee and tea play an important role in modulating disease-risk in humans by suppressing tumor progression, decreasing inflammation and influencing estrogen metabolism, mechanisms that may be mediated by epigenetic changes.

(Tea Consumption: Epigenetic Changes in Women, Editura Global Info)

Anti-CTLA4 MoAb RNA/GITRL RNA-transfected DC vaccine is prepared by transfecting DCs with RNAs encoding humanized heavy and light chains of the anti-CTLA4 (cytotoxic T-Lymphocyte-Associated Antigen 4) monoclonal antibody and tumor necrosis factor (ligand) superfamily, member 18 (TNFSF18 or GlTRL); expression of anti-CTLA4 blocks the inhibitory effect of CTLA4 on the activation of T-lymphocytes, while expression of GlTRL modulates T lymphocyte survival in peripheral tissues.

(Anti-CTLA4 MoAb RNA/GITRL RNA-transfected Autologous Dendritic Cell Vaccine, NCI Thesaurus)

Although the exact mechanism through which the anti-angiogenesis effect remains to be fully elucidated, oltipraz maybe able to modulate the expression of a number of angiogenic factors, thereby blocking the sustained and focal neovascularization in multiple tumor cell types.

(Oltipraz, NCI Thesaurus)

It may be possible to modulate miRNAs in the brain for the treatment of psychiatric disorders but research in this area has faced several challenges, for example, finding safe and biologically stable compounds that are able to cross the blood-brain barrier and then act at the desired location in the brain.

(New Light on Link between Gut Bacteria, Anxiety, Editura Global Info)

Upon oral consumption, the ingredients in this herbal supplement may modulate the activity of the immune system through a decrease in both the expression of nuclear factor-kappa B (NF-kappa B) and the production of pro-inflammatory cytokines such as interleukin-1beta (Il-1b), IL-6, and tumor necrosis factor-alpha (TNF-alpha).

(Astragalus-based Formulation Qing Shu Yi Qi Tang, NCI Thesaurus)

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