INHIBIT

Pronunție (USA): (GB):

Traducere în limba română

inhibit verb tranzitiv

1. (from) (rar, jur. etc.) a opri (de la), a interzice, a prohibi.

2. (bis.) a caterisi, a suspenda (un preot).

3. (to, from) a opri, a reţine (de la, de a), a impiedica (de a).

4. (med.) a paraliza (o secreţie etc.).

5. (fiziol.) a ihhiba.

Exemple de propoziții și/sau fraze:

In addition, this agent has been shown to inhibit homologous recombination (HR) activity by inhibiting the expression of RAD51.

(Abexinostat, NCI Thesaurus)

Given their finding that PHD proteins suppress the inflammatory immune response in the lung, the researchers wondered whether inhibiting them might improve the efficacy of adoptive cell transfer, a type of immunotherapy that harnesses the ability of a patient’s own T cells to recognize and attack cancer.

(Oxygen can impair cancer immunotherapy in mice, NIH)

An agent that inhibits both mitogen-activated protein kinase kinases 1 and 2 (MEK1 and MEK2), substrates of Raf and phosphorylates extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2), preventing phosphorylation and activation of the Mitogen-Activated Protein Kinase (MAPK) pathways, involved with signal transduction pathways and tumor proliferation.

(MEK Inhibitor CI-1040, NCI Thesaurus)

Memantine binds to and inhibits cation channels of glutamanergic NMDA receptors located in the central nervous system (CNS), preventing the prolonged influx of calcium ions and the associated neuronal excitotoxicity, and thereby potentially enhancing cognitive function.

(Memantine hydrochloride, NCI Thesaurus)

These agents display potent antitumor properties due to their ability to intercalate into DNA and interfere with the function of both the topoisomerase I and II enzymes, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis.

(Aclacinomycin Antitumor Antibiotic, NCI Thesaurus)

MEK1/2 inhibitor AS703988/MSC2015103B selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation.

(MEK 1/2 Inhibitor AS703988/MSC2015103B, NCI Thesaurus)

MEK inhibitor WX-554 selectively binds to and inhibits the activity of MEK, thereby preventing the activation of MEK-dependent effector proteins including some transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation.

(MEK Inhibitor WX-554, NCI Thesaurus)

MEK inhibitor TAK-733 selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation.

(MEK Inhibitor TAK-733, NCI Thesaurus)

Abexinostat inhibits several isoforms of HDAC, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling; the selective transcription of tumor suppressor genes; and the tumor suppressor protein-mediated inhibition of tumor cell division and induction of tumor cell apoptosis.

(Abexinostat, NCI Thesaurus)

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