ACTIVATION

Pronunție (USA): (GB):

Traducere în limba română

activation substantiv

(tehn.) activ(iz)are.

Exemple de propoziții și/sau fraze:

In 2012, a team identified a molecule known as BMP8b that regulates the activation of brown fat in both the brain and the body’s tissues.

(Study in mice suggests drug to turn fat ‘brown’ could help fight obesity, University of Cambridge)

A team of scientists investigated antimicrobial gene activation during infection to better understand the body’s immune response to microbes.

(Drug might help treat sepsis, NIH)

Activation of the NMDA receptor is thought to play a role in learning and memory.

(Structure of receptor involved in brain disorders, NIH)

Each cell-surface integral membrane protein receptor contains a 7 transmembrane domain and interacts with a heterotrimeric G protein complex in response to adenosine ligand to stimulate or suppress cAMP accumulation through adenylate cyclase activation or inhibition.

(Adenosine Receptor, NCI Thesaurus)

In addition, the researchers found that mice were willing to work for activation in this brain area and to spend time in conditions they would usually not prefer (light vs. darker areas) to receive this activation.

(New Findings Reveal Surprising Role of the Cerebellum in Reward and Social Behaviors, National Institutes of Health)

Adenosine receptor A2b protein (332 aa, 36 kD) is a cell communication protein that is encoded by the human ADORA2B gene and has roles in adenylate cyclase activation, MAPK activation, JNK cascade activation, cellular defense response and excretion.

(Adenosine Receptor A2b, NCI Thesaurus)

An agent that inhibits both mitogen-activated protein kinase kinases 1 and 2 (MEK1 and MEK2), substrates of Raf and phosphorylates extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2), preventing phosphorylation and activation of the Mitogen-Activated Protein Kinase (MAPK) pathways, involved with signal transduction pathways and tumor proliferation.

(MEK Inhibitor CI-1040, NCI Thesaurus)

IL-12 expressed by the adenovirus may activate the immune system by promoting the activation of natural killer cells (NKs), inducing secretion of interferon-gamma and inducing cytotoxic T cell responses against tumor cells, which may result in immune-mediated tumor cell death and inhibition of tumor cell proliferation.

(Adenovirus-mediated Human Interleukin-12 INXN-2001 Plus Activator Ligand INXN-1001, NCI Thesaurus)

MEK1/2 are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway that regulates cell growth and are often upregulated in a variety of tumor cell types.

(MEK 1/2 Inhibitor AS703988/MSC2015103B, NCI Thesaurus)

MEK, a dual specificity threonine/tyrosine kinase, is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers.

(MEK Inhibitor RO4987655, NCI Thesaurus)

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